Marked Intratumoral Heterogeneity of c-myc and CyclinD1 But Not of c-erbB2 Amplification in Breast Cancer
نویسندگان
چکیده
منابع مشابه
Abnormal FHIT gene transcript and c-myc and c-erbB2 amplification in breast cancer.
Searching for ways to improve the characterization of breast cancer we examined the relationship between the status of the FHIT gene transcript and amplification of c-myc and the c-erbB2 oncogene. Abnormal FHIT transcript was detected in 32 of 79 cancers examined. The presence of Fhit protein estimated by Western blots was evident only in cancers exhibiting a normal-sized FHIT transcript. This ...
متن کاملAmplification of c-myc but not of c-erbB-2 is associated with high proliferative capacity in breast cancer.
Proliferative capacity provides an independent prognostic marker of progression in breast cancer. Little is known about the molecular mechanisms influencing the cell division rate in mammary carcinomas. In order to address this issue, the copy numbers of c-erbB-2 (HER/neu) and c-myc protooncogenes that have been shown to be amplified in aggressive types of cancers were determined in 60 mammary ...
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The routine multidisciplinary management of colon cancer is based mainly on tumor staging, histology, grading and vascular invasion. In this approach, important individual information derived from molecular characteristics of the tumor may be missed, especially since significant heterogeneity of molecular aberrations in cancer cells has been observed, and recognition of every of relationships b...
متن کاملAmplification of c-myc but not of c-erbB-2 Is Associated with High Proliferative Capacity in Breast Cancer1
Proliferative capacity provides an independent prognostic marker of progression in breast cancer. Little is known about the molecular mech anisms influencing the cell division rate in mammary carcinomas. In order to address this issue, the copy numbers of c-irMl-2 (HER/neu) and c-myc protooncogenes that have been shown to be amplified in aggressive types of cancers were determined in 60 mammary...
متن کاملc-Myc in breast cancer.
Ever since Bishop and his co-workers discovered the c-myc gene in the late 1970s (Bishop 1982), voluminous literature has documented its central role in proliferation and malignant transformation of human and animal cells (Amati et al. 1998, Bouchard et al. 1998, Dang et al. 1999). Most, if not all, types of human malignancy have been reported to have amplification and/or overexpression of this...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2002
ISSN: 0023-6837,1530-0307
DOI: 10.1097/01.lab.0000032371.16521.40